Selective nitrergic neurodegeneration in diabetes mellitus-a nitric oxide-dependent phenomenon
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چکیده
منابع مشابه
The Role of Nitric Oxide Donors in Wound Healing in Diabetes Mellitus
Introduction: Diabetic foot ulcer is a serious complication of diabetes mellitus; it consists of lesions in the deep tissues associated with neurological disorders and peripheral vascular disease in the lower limbs. Delayed wound healing in diabetes leads to long-term hospitalization and even amputation of distal organs. Diabetes mellitus is associated with decreased nitric oxide bioavailabilit...
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Fas is an apoptosis-inducing surface receptor involved in controlling tissue homeostasis and function at multiple sites. Here we show that beta cells from the pancreata of newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients express Fas and show extensive apoptosis among those cells located in proximity to Fas ligand-expressing T lymphocytes infiltrating the IDDM islets. Normal h...
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The mechanism of release of proinflammatory cytokines by blood granulocytes in diabetes is unknown. We investigated whether diabetes mellitus affects the production of cytokines by granulocytes (PMN) and mononuclear cells (PBMCs) and whether this is modulated by NO. Isolated PMN and PBMC from with or without type-II diabetes mellitus were incubated at 37°C for 6 h with S-nitroso-N-acetylpenicil...
متن کاملNitric-oxide synthase and neurodegeneration/neuroprotection.
Glaucoma is an optic neuropathy in which the retinal ganglion cells and their axons, which package and transmit visual impulses from the photoreceptors and associated retinal interneurons to the brain, die individually or in small groups, typically over many years (Figs. 1 and 2) (1). The resulting functional deficit is the second leading cause of irreversible visual loss in the U.S., and the m...
متن کاملTwo phases of nitrergic neuropathy in streptozotocin-induced diabetic rats.
The distinction between metabolic and structural changes occurring in autonomic neurons during diabetes has not been fully clarified. Here we demonstrate that nitric oxide synthase-containing (nitrergic) neurons innervating the penis and gastric pylorus of streptozotocin-induced diabetic rats undergo a selective degenerative process in two phases. In the first phase, nitrergic nerve fibers lose...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1999
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0702981